Journal of Cancer Research and Therapeutics Close
 

Figure 4: Functional impact of the observed mutations on the encoded TP53 proteins. Structurally, mutant TP53 proteins were compared with normal TP53 protein. This comparison revealed that various important domains are missed in mutant TP53 proteins due to the formation of premature termination codon (opal) and (ocher) at position 59 and 239. Premature termination codons unable mutant TP53 proteins to activate their target genes (p21, BCL-2, Bcl-2-associated X protein)

Figure 4: Functional impact of the observed mutations on the encoded TP53 proteins. Structurally, mutant TP53 proteins were compared with normal TP53 protein. This comparison revealed that various important domains are missed in mutant TP53 proteins due to the formation of premature termination codon (opal) and (ocher) at position 59 and 239. Premature termination codons unable mutant TP53 proteins to activate their target genes (p21, BCL-2, Bcl-2-associated X protein)