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Figure 3: Funnel plots: (a) Distribution of KRAS mutations in distal and proximal colorectal tumors: Funnel plots are symmetrical, so there is no publication bias. (b) Distribution of BRAF mutations in distal and proximal colorectal tumors: Funnel plots are asymmetrical at the bottom, and the included studies are far off the central axis, which indicates a publication bias. (c) Distribution of KRAS mutations in CpG island methylator phenotype-low/negative and CpG island methylator phenotype-high tumors: Funnel plots are basically symmetrical, so there is no publication bias. (d) Distribution of BRAF mutations in CpG island methylator phenotype-low/negative and CpG island methylator phenotype-high tumors: Funnel plots are asymmetrical, which indicates a publication bias. (e) Distribution of KRAS mutations in microsatellite instability-low/microsatellite stable and microsatellite instability-high tumors: Funnel plots are basically symmetrical, so there is no publication bias. (f) Distribution of BRAF mutations in microsatellite instability-low/microsatellite stable and microsatellite instability-high tumors: Funnel plots are symmetrical, so there is no publication bias. (g) Distribution of CpG island methylator phenotype-high tumors among distal and proximal colorectal tumors: Funnel plots are asymmetrical, which indicates a publication bias. (h) Distribution of microsatellite instability-high tumors among distal and proximal colorectal tumors: Funnel plots are asymmetrical, which indicates a publication bias. (i) Distribution of CpG island methylator phenotype-high tumors among microsatellite instability-low/microsatellite stable and microsatellite instability-high tumors: Funnel plots are basically symmetrical, so there is no publication bias

Figure 3: Funnel plots: (a) Distribution of <i>KRAS</i> mutations in distal and proximal colorectal tumors: Funnel plots are symmetrical, so there is no publication bias. (b) Distribution of <i>BRAF</i> mutations in distal and proximal colorectal tumors: Funnel plots are asymmetrical at the bottom, and the included studies are far off the central axis, which indicates a publication bias. (c) Distribution of <i>KRAS</i> mutations in CpG island methylator phenotype-low/negative and CpG island methylator phenotype-high tumors: Funnel plots are basically symmetrical, so there is no publication bias. (d) Distribution of <i>BRAF</i> mutations in CpG island methylator phenotype-low/negative and CpG island methylator phenotype-high tumors: Funnel plots are asymmetrical, which indicates a publication bias. (e) Distribution of <i>KRAS</i> mutations in microsatellite instability-low/microsatellite stable and microsatellite instability-high tumors: Funnel plots are basically symmetrical, so there is no publication bias. (f) Distribution of <i>BRAF</i> mutations in microsatellite instability-low/microsatellite stable and microsatellite instability-high tumors: Funnel plots are symmetrical, so there is no publication bias. (g) Distribution of CpG island methylator phenotype-high tumors among distal and proximal colorectal tumors: Funnel plots are asymmetrical, which indicates a publication bias. (h) Distribution of microsatellite instability-high tumors among distal and proximal colorectal tumors: Funnel plots are asymmetrical, which indicates a publication bias. (i) Distribution of CpG island methylator phenotype-high tumors among microsatellite instability-low/microsatellite stable and microsatellite instability-high tumors: Funnel plots are basically symmetrical, so there is no publication bias