Figure 2: Localization of growth arrest and DNA damage inducible (Gadd45a) in human oral tissues. (a) Gadd45a was expressed with nucleus-dominant pattern in pericancerous tissue. (b) Well differentiated oral carcinoma tissue showed staining for Gadd45a in the nuclei and cytoplasm (nucleus-dominant pattern). (c) Poorly differentiated oral carcinoma tissue showed overexpression of Gadd45a in cell cytoplasm (cytoplasm-dominant pattern)