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Figure 2: (a) Microphotograph shows diffuse infiltration by small cells having high nucleo-cytoplasmic ratio with small nucleoli, scant cytoplasm, and indistinct nuclei. Microphotograph of immunohistochemistry showing immunopositive for (b) CD4 (X200), (c) CD43, (d) Alk1 (X200) and negative for (e) CD56 (X200). Flowcytometry analysis shows positive for (f) CD123 and H. CD33while negative for (g) CD56 and CD34. (Case 2) (h) Microphotograph shows diffuse infiltration by small cells having high nucleo-cytoplasmic ratio with small nuclei and scant cytoplasm (H and E ×200). (i)Biopsy from skin nodule shows intermediate size cell with scant cytoplasm. (J)Fine-needle aspiration cytology shows cells with moderate cytoplasm and fine granular chromatin and indistinct nuclei (MGG ×1000). Microphotograph of immunohistochemistry showing immunopositive for (k) LCA (n) CD4 (×200), (o) CD43 (×200), (p) LCD56 (×200), while negative for (l) CD3 (×200), (m) TDT and (q) MPO (×200). Flowcytometry analysis shows positive for ®CD4, CD43, (s) CD4 and CD56, (t) CD123 and HLADR while negative for (u) CD3and MPO

Figure 2: (a) Microphotograph shows diffuse infiltration by small cells having high nucleo-cytoplasmic ratio with small nucleoli, scant cytoplasm, and indistinct nuclei. Microphotograph of immunohistochemistry showing immunopositive for (b) CD4 (X200), (c) CD43, (d) Alk1 (X200) and negative for (e) CD56 (X200). Flowcytometry analysis shows positive for (f) CD123 and H. CD33while negative for (g) CD56 and CD34. (Case 2) (h) Microphotograph shows diffuse infiltration by small cells having high nucleo-cytoplasmic ratio with small nuclei and scant cytoplasm (H and E ×200). (i)Biopsy from skin nodule shows intermediate size cell with scant cytoplasm. (J)Fine-needle aspiration cytology shows cells with moderate cytoplasm and fine granular chromatin and indistinct nuclei (MGG ×1000). Microphotograph of immunohistochemistry showing immunopositive for (k) LCA (n) CD4 (×200), (o) CD43 (×200), (p) LCD56 (×200), while negative for (l) CD3 (×200), (m) TDT and (q) MPO (×200). Flowcytometry analysis shows positive for ®CD4, CD43, (s) CD4 and CD56, (t) CD123 and HLADR while negative for (u) CD3and MPO