Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 14  |  Issue : 1  |  Page : 119--123

Lipopolysaccharide promoted the growth rate of MG-63 cells via the extracellular regulated kinase pathway


Xiaobo Niu, Hao Peng 
 Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China

Correspondence Address:
Dr. Hao Peng
Department of Orthopedics, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan, Hubei 430060
PR China

Objective: The objective of this study is to investigate the effects of lipopolysaccharide (LPS) on the growth rate of MG-63 cells. Materials and Methods: MG-63 cells were exposed to various concentrations of LPS, and the growth rate was determined with the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. In addition, variations in the phosphorylation state of extracellular regulated kinase (ERK1/2), Jun N-terminal kinase, and p38 were determined by western blotting. Results: There was a correlation between the increased phosphorylation of ERK1/2 and the growth of LPS-treated MG-63 cells. The increased phosphorylation was mediated by the LPS receptor toll-like receptor-4. Conclusions: LPS promoted the growth of MG-63 cells through the ERK pathway.


How to cite this article:
Niu X, Peng H. Lipopolysaccharide promoted the growth rate of MG-63 cells via the extracellular regulated kinase pathway.J Can Res Ther 2018;14:119-123


How to cite this URL:
Niu X, Peng H. Lipopolysaccharide promoted the growth rate of MG-63 cells via the extracellular regulated kinase pathway. J Can Res Ther [serial online] 2018 [cited 2022 Sep 25 ];14:119-123
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=1;spage=119;epage=123;aulast=Niu;type=0