Journal of Cancer Research and Therapeutics

REVIEW ARTICLE
Year
: 2012  |  Volume : 8  |  Issue : 4  |  Page : 520--527

Autoimmunity in the elderly: Implications for cancer


Michele Malaguarnera1, Erika Cristaldi1, Giulia Romano1, Lucia Malaguarnera2 
1 Department of Internal Medicine and Systemic Pathologies, University of Catania, Italy
2 Department of Biomedical Sciences, University of Catania, Italy

Correspondence Address:
Erika Cristaldi
Department of Internal Medicine and Systemic Pathologies, Azienda Ospedaliera «DQ»Cannizzaro«DQ», via Messina 829, 95124 Catania
Italy

Immunosenescence is the aging process involving the immune system competencies. These changes imply a reduced level of immunosurveillance against cancer onset and the occurrence of autoimmune phenomena. The clinical presentation of autoimmune diseases in the elderly is characterized in most cases by atypical features, insidious presentation and poor specificity of laboratory parameters. The role of autoimmune reactivity in the elderly either as a consequence of or as a risk factor for cancer development has aroused great interest among clinicians and researchers, as well as the influence of a chronic inflammatory state as a predisposing factor for autoimmunity and cancer occurrence. Particularly, we have investigated the pathogenetic effect of two cell subsets, Treg cells and Th17 lymphocytes, involved in the control mechanisms both of autoimmune reactions and cancer onset, as the possible future approach to treat cancer in older adults.


How to cite this article:
Malaguarnera M, Cristaldi E, Romano G, Malaguarnera L. Autoimmunity in the elderly: Implications for cancer.J Can Res Ther 2012;8:520-527


How to cite this URL:
Malaguarnera M, Cristaldi E, Romano G, Malaguarnera L. Autoimmunity in the elderly: Implications for cancer. J Can Res Ther [serial online] 2012 [cited 2022 May 18 ];8:520-527
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2012;volume=8;issue=4;spage=520;epage=527;aulast=Malaguarnera;type=0