Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2007  |  Volume : 3  |  Issue : 2  |  Page : 81--85

A prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer


KP Haresh1, PK Julka1, DN Sharma1, GK Rath1, R Prabhakar1, A Seth2 
1 Department of Radiotherapy, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi - 110 029, India
2 Department of Urology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi - 110 029, India

Correspondence Address:
K P Haresh
Dept. of Radiotherapy, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi - 110 029
India

Aim : The aim of our study was to compare the two standard treatment approaches in muscle invasive carcinoma of urinary bladder - radical cystectomy and chemo radiation. Materials and Methods : Transitional cell carcinoma (TCC) of bladder of stages, T2 to T4, N0/N1/N2 and MO were included in the study. Patients were allotted to two arms of the study. Arm A consisted of radical cystectomy. Adjuvant CMV chemotherapy was given for T3/T4 or Node positive disease only. Arm B received 2 cycles of neoadjuvant CMV chemo therapy followed by concurrent chemo radiation Results : Forty-four patients were recruited into the study. Thirty patients in the surgical arm and 13 patients in the chemo radiation arm. The actuarial two-year survival rate in surgical arm is 56% while in chemo radiation arm it is 54%. There was no statistically significant difference in disease-free survival also between the two groups. Conclusion : Chemo radiation yielded equivalent survival results with radical cystectomy. So it is worth giving preference to chemo radiation that will give a better quality of life for the patient.


How to cite this article:
Haresh K P, Julka P K, Sharma D N, Rath G K, Prabhakar R, Seth A. A prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer.J Can Res Ther 2007;3:81-85


How to cite this URL:
Haresh K P, Julka P K, Sharma D N, Rath G K, Prabhakar R, Seth A. A prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer. J Can Res Ther [serial online] 2007 [cited 2022 May 18 ];3:81-85
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2007;volume=3;issue=2;spage=81;epage=85;aulast=Haresh;type=0