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Discoidin domain receptor 1 as a promising biomarker for high-grade gliomas


1 Department of Medical Oncology, VM Samsun Medicalpark Hospital, İstanbul, Turkey
2 Department of Medical Oncology, Istanbul Aydin University VM Medical Park Florya Hospital, İstanbul, Turkey
3 Bahcesehir University School of Medicine, İstanbul, Turkey
4 Department of Neurosurgery, Faculty of Medicine, Balıkesir University, Balikesir, Turkey
5 Department of Neurosurgery, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey
6 Department of Neurosurgery, Medipol Hospital, İstanbul, Turkey
7 Department of Medical Biology, Balıkesir University School of Medicine, Balikesir, Turkey
8 Department of Biochemistry, Health Sciences University, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
9 Department of Neurosurgery and Psychiatry, University of Health Sciences, Bakırköy Prof. Dr. Mazhar Osman Training and Research Hospital for Neurology, İstanbul, Turkey

Correspondence Address:
Dilek Erdem,
Department of Medical Oncology, VM Samsun Medicalpark Hospital, Mimarsinan, Alparslan Blv. No:17, 55200 Atakum/Samsun
Turkey
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.jcrt_708_21

Background: Two fundamental challenges in the current therapeutic approach for central nervous system tumors are the tumor heterogeneity and the absence of specific treatments and biomarkers that selectively target the tumor tissue. Therefore, we aimed to investigate the potential relationship between discoidin domain receptor 1 (DDR1) expression and the prognosis and characteristics of glioma patients. Materials and Methods: Tissue and serum samples from 34 brain tumor patients were evaluated for DDR1 messenger ribonucleic acid levels in comparison to 10 samples from the control group, and Kaplan–Meier survival analysis has performed. Results: DDR1 expression was observed in both tissue and serum samples of the patient and control groups. DDR1 expression levels in tissue and serum samples from patients were higher in comparison to the control group, although not statistically significant (P > 0.05). A significant correlation between tumor size and DDR1 serum measurements at the level of 0.370 was reported (r = 0.370; P = 0.034). The levels of DDR1 in serum showed a positive correlation with the increasing size of tumor. The results of the 5-year survival analysis depending on the DDR1 tissue levels showed a significantly higher survival rate (P = 0.041) for patients who have DDR1 tissue levels above cutoff value. Conclusions: DDR1 expression was significantly higher among brain tumor tissues and serum samples and its levels showed a positive correlation with the increased size of tumor. This study can be a starting point, since it investigated and indicated, for the first time, that DDR1 can be a novel therapeutic and prognostic target for aggressive high-grade gliomas.


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    -  Erdem D
    -  Gunaldi M
    -  Karaman I
    -  Adilay U
    -  Yılmaz &U
    -  Eseoglu M
    -  Avcıkurt A
    -  Isıksacan N
    -  Erdogan U
    -  Gunaldi O
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