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LETTER TO THE EDITOR
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Vitamin D supplementation and serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A summary of clinical evidences from a tropical country with a high incidence of hepatitis-related hepatocellular carcinoma


1 Private Academic Consultant, Bangkok, Thailand
2 Department of Honorary, Dr DY Patil University, Pune, Maharashtra, India

Date of Submission24-Feb-2021
Date of Decision24-Mar-2021
Date of Acceptance25-Mar-2021
Date of Web Publication15-Feb-2022

Correspondence Address:
Pathum Sookaromdee,
Private Academic Consultant, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.jcrt_320_21



How to cite this URL:
Sookaromdee P, Wiwanitki V. Vitamin D supplementation and serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A summary of clinical evidences from a tropical country with a high incidence of hepatitis-related hepatocellular carcinoma. J Can Res Ther [Epub ahead of print] [cited 2022 Nov 29]. Available from: https://www.cancerjournal.net/preprintarticle.asp?id=337712



Dear Editor,

Hepatitis C is an important viral infection. This infection is common in East and South Asia and it is an important cause of hepatocellular carcinoma in the endemic area. The early management of the infection by antiviral therapy is commended aiming at decreased hepatic fibrogenesis that can further progress to carcinogenesis. Adding to antiviral therapy, nutritional supplementation is also proposed for its usefulness in managing chronic hepatitis C. Vitamin D supplementation is recommended.[1],[2]

The effect of Vitamin D supplementation in the management of chronic hepatitis C cases is interesting. In a report from India,[3] Behera et al. found that there is no significant effect. However, a report from Thailand presented a different finding that Vitamin D supplementation is useful.[4] Among the reports from the same area such as Thailand, a country with a high incidence of hepatitis C and hepatitis-related hepatocellular carcinoma, the inconclusive results are observed.[4],[5] Here, the authors perform a summative analysis on the available data on trials on Vitamin D supplementation and serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients in Thailand.

Based on the two available clinical trials, there are overall 66 and 67 cass in vitamin D supplementation and control groups. The observed fibrogenic markers (transforming growth factor-beta 1 and tissue inhibitors of matrix metalloproteinases 1) at 6 weeks are summarized and analyzed using ANOVA [Table 1]. According to this analysis, there is no specific difference of both the studied biomarkers at pre-and post-vitamin D supplementation in both vitamin D supplementation and placebo group (P > 0.05). This can imply that vitamin D supplementation might not affect hepatic fibrogenesis prevention in chronic hepatitis C. The usefulness of Vitamin D supplementation for the prevention of hepatitis-associated hepatocellular carcinoma has to be re-evaluated.
Table 1: Effect of Vitamin D supplementation on serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients

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Conflicts of interest

There are no conflicts of interest.



 
 > References Top

1.
Kondo Y. Hepatitis C infected patients need Vitamin D3 supplementation in the era of direct acting antivirals treatment. World J Gastroenterol 2017;23:1325-7.  Back to cited text no. 1
    
2.
Lange CM, Miki D, Ochi H, Nischalke HD, Bojunga J, Bibert S, et al. Genetic analyses reveal a role for Vitamin D insufficiency in HCV-associated hepatocellular carcinoma development. PLoS One 2013;8:e64053.  Back to cited text no. 2
    
3.
Behera MK, Shukla SK, Dixit VK, Nath P, Abhilash VB, Asati PK, et al. Effect of Vitamin D supplementation on sustained virological response in genotype 1/4 chronic hepatitis C treatment-naïve patients from India. Indian J Med Res 2018;148:200-6.  Back to cited text no. 3
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4.
Komolmit P, Kimtrakool S, Suksawatamnuay S, Thanapirom K, Chattrasophon K, Thaimai P, et al. Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study. Sci Rep 2017;7:8905.  Back to cited text no. 4
    
5.
Sriphoosanaphan S, Thanapirom K, Kerr SJ, Suksawatamnuay S, Thaimai P, Sittisomwong S, et al. Effect of Vitamin D supplementation in patients with chronic hepatitis C after direct-acting antiviral treatment: A randomized, double-blind, placebo-controlled trial. PeerJ 2021;9:e10709.  Back to cited text no. 5
    



 
 
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