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Primary pulmonary NUT midline carcinoma: An elusive and a rare diagnostic entity


1 Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
2 Department of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
3 Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
4 Department of Molecular Diagnostics Radiology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
5 Department of Laboratory, Molecular and Transfusion Services, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India

Correspondence Address:
Divya Bansal,
Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi - 110 085
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.jcrt_1887_20

Nuclear protein in testis (NUT) midline carcinoma is a poorly differentiated tumor, is more common in midline anatomic sites, and involves young adults and children mainly. Primary pulmonary NUT midline carcinoma (NMC) is a rare and poorly defined entity in the prevailing literature. Being a highly aggressive and fatal neoplasm, it gets incumbent for the oncologists and the pathologists to be aware of this entity as it holds distinct management protocol and prognosis. Currently, BET inhibitors (BETi) and histone deactylase inhibitors have shown promising results as targeted therapies in clinical trials in head and neck NMC. We present a case report of NMC of primary pulmonary location in a young male with widespread bony metastasis.


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    -  Pasricha S
    -  Jajodia A
    -  Sharma A
    -  Bansal D
    -  Batra U
    -  Gupta G
    -  Durga G
    -  Kamboj M
    -  Nathany S
    -  Mehta A
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