|LETTER TO THE EDITOR
|Ahead of print publication
Anticancer property of Zika virus proteins: Lack of evidence from predictive clinical bioinformatics study
Beuy Joob1, Viroj Wiwanitkit2
1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Department of Biological Science, Joseph Ayobabalola University, Ikeji-Arakeji, Osun State, Nigeria
|Date of Submission||27-Aug-2019|
|Date of Decision||30-Dec-2019|
|Date of Acceptance||30-Dec-2019|
|Date of Web Publication||10-May-2021|
Sanitation 1 Medical Academic Center, Bangkok
Source of Support: None, Conflict of Interest: None
Zika virus infection is an important arbovirus infection that still presents with global public health consideration. In clinical oncology, the infection might occur in cancerous patients and becomes an important consideration for proper patient care. In addition, the previous study also showed that Zika virus is not a carcinogenic pathogen. Some researchers mentioned that Zika virus might be useful for cancer treatment. Chen et al. proposed that Zika virus-based vaccine might be useful in glioma management. In a recent mouse model experiment, some proteins of Zika virus showed a possible inhibitory activity against tumor cells. Nevertheless, there has been no research regarding the anticancer property of Zika virus.
Similar to the previous report, hereby the authors use clinical bioinformatics approach for prediction on the anticancer properties of Zika virus proteins. Overall, 1454 Zika virus proteins derived from PubMED database were tested for anticancer property using a standard clinical informatics tool namely MLACP. The technique is an artificial intelligence approach based on structural–function comparison between the studied proteins and referenced anticancer compounds. According to the present report, none of the 1454 Zika virus proteins show anticancer property. Based on this study, it can be concluded that Zika virus protein might not be useful for cancer therapy.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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