Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 

Ahead of print publication  

Metabolic syndrome: A patient-related prognostic factor for cancer?

1 Cancer Cytogenomic Laboratory, Federal University of Ceará: Brazilian Company of Hospital Services, University Hospital Walter Cantidio, Fortaleza, Brazil
2 Department of Clinical Medicine, Cancer Cytogenomic Laboratory, Federal University of Ceará, Fortaleza, Brazil

Date of Submission07-May-2019
Date of Acceptance23-Oct-2019
Date of Web Publication27-Apr-2021

Correspondence Address:
Priscila da Silva Mendonça,
Cancer Cytogenomic Laboratory, Federal University of Ceará, Fortaleza: Brazilian Company of Hospital Services, University Hospital Walter Cantidio, Fortaleza
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_323_19

How to cite this URL:
Mendonça Pd, Aguiar AP, Pinheiro RF, Magalhães SM. Metabolic syndrome: A patient-related prognostic factor for cancer?. J Can Res Ther [Epub ahead of print] [cited 2022 Dec 4]. Available from: https://www.cancerjournal.net/preprintarticle.asp?id=314861


We read with interest the article recently published by Caliskan et al.[1] The authors prospectively assessed the effect of metabolic syndrome (MetS) on prostate cancer final pathology of 117 patients. A significant increased prostate-specific antigen level and a higher prevalence of advanced disease were observed among prostate cancer individuals with MetS. In this regard, we would like to discuss and complement these findings, in special to comment on the impact of MetS on prognostic factor of different tumors.

The global worldwide prevalence of obesity and other noncommunicable diseases is increasing dramatically. Obesity is the major determinant of MetS, defined as a cluster of risk factors for heart disease, stroke, and diabetes mellitus. It includes increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.

In a large systematic review and meta-analysis, the presence of MetS was strongly associated with increased risk of some cancers. The results of studies differ according to ethnicity and gender.[2] However, epidemiological studies on the association between MetS and cancer prognosis and outcome have been relatively scarce.

We conducted an electronic search for articles about the effect of MetS on the prognosis of different types of cancer. We selected three studies that evaluated MetS and its impact on breast, colorectal, and general cancers.[3],[4],[5] We have found strong evidence of the association between MetS and cancer outcomes [Table 1].
Table 1: The effect of myelodysplastic syndrome on cancer prognosis and outcome

Click here to view

In addition, in a prospective study performed by our group, 91 sequential myelodysplastic syndrome (MDS) patients were evaluated. MDS is a heterogeneous group of hematologic cancer characterized by ineffective hematopoiesis that leads to peripheral blood cytopenias and an increased risk of evolution to acute myeloid leukemia and mainly affects the older population.

The mean age of MDS patients was 71.6 years ± 11.4 (38–96). MetS was diagnosed in 41.8% (n = 38) of patients. There were a significant association between MetS and older patients (≥65 years) (P = 0.04) and a significant association between MetS and transfusion dependency (DT) (P = 0.04). DT is an important and severe prognostic factor for MDS and other hematologic diseases. No significant association was observed between other hematologic markers (hemoglobin, neutrophil count, platelets, and bone marrow blast percentage).

Beyond classic disease-related prognostic factors, comorbidities and other patient-related prognostic factors are well known to negatively impact outcomes. Chronic pathologies, as MetS, have become an important leading cause of nondisease-related death among this population. It is highly recommended that all cancer patients have a careful general assessment at the time of diagnosis and during the course of the disease and that prevention measures are implemented.

Financial support and sponsorship

This study was conducted with partial support from the National Council for Scientific and Technological Development and the Brazilian Company of Hospital Services.

Conflicts of interest

There are no conflicts of interest.

 > References Top

Caliskan S, Kaba S, Özsoy E, Keleş MO, Koca O, Akyüz M, et al. The effect of metabolic syndrome on prostate cancer final pathology. J Cancer Res Ther 2019;15:S47-50.  Back to cited text no. 1
Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D. Metabolic syndrome and risk of cancer: A systematic review and meta-analysis. Diabetes Care 2012;35:2402-11.  Back to cited text no. 2
Dibaba DT, Braithwaite D, Akinyemiju T. Metabolic syndrome and the risk of breast cancer and subtypes by race, menopause and BMI. Cancers (Basel) 2018;10. pii: E299.  Back to cited text no. 3
Shariq OA, Hanson KT, McKenna NP, Kelley SR, Dozois EJ, Lightner AL, et al. Does metabolic syndrome increase the risk of postoperative complications in patients undergoing colorectal cancer surgery? Dis Colon Rectum 2019;62:1-10.  Back to cited text no. 4
Gathirua-Mwangi WG, Monahan PO, Murage MJ, Zhang J. Metabolic syndrome and total cancer mortality in the third national health and nutrition examination survey. Cancer Causes Control 2017;28:127-36.  Back to cited text no. 5


  [Table 1]


     Search Pubmed for
    -  Mendonça Pd
    -  Aguiar AP
    -  Pinheiro RF
    -  Magalhães SM
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  >Article Tables
  In this article

 Article Access Statistics
    PDF Downloaded14    

Recommend this journal