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Fibromatosis mimicking relapse of a neuroendocrine tumor at 68Ga-DOTATOC positron-emission tomography/computed tomography

1 Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy
2 Department of Oncology, San Giovanni Bosco Hospital, Torino, Italy
3 Unit of Pathology, San Giovanni Bosco Hospital, Torino, Italy

Correspondence Address:
Elena Trevisi,
Department of Oncology, San Luigi Gonzaga Hospital, Regione Gonzole, 10, 10043 Orbassano
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_802_19

Mesenteric fibromatosis (desmoid tumor) is a locally aggressive fibroblastic lesion, characterized by a high recurrence rate that makes treatment challenging. Currently, there is no evidence-based treatment approach. We report the case of a female patient with a history of neuroendocrine tumor, who underwent 68Ga-DOTATOC positron-emission tomography/computed tomography (PET/CT), showing increased focal abdominal uptake suggestive of disease relapse. Histological examination revealed typical findings of fibromatosis. These findings indicate the expression of staining for somatostatin receptors (SSTRs) on fibromatosis cell surface and suggest to include fibromatosis among the potential causes of false-positive results at 68Ga PET/CT. Moreover, SSTRs expressed in desmoid tumors could be further investigated as a therapeutic target.

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