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Gastric cancer in Jammu and Kashmir, India: A review of genetic perspectives

1 Department of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India
2 Division of Thoracic Surgery, Medstar Washington Hospital Center, Georgetown University School of Medicine, Washington, DC, USA
3 Department of Radiation Oncology, The Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX, USA
4 Department of Medicine, Division of Gastroenterology, Acharya Shri Chander College of Medical Sciences, Jammu, Jammu and Kashmir, India
5 Department of Pathology, Government Medical College and Hospital, Jammu, Jammu and Kashmir, India
6 Department of Surgical Oncology, Shri Mata Vaishno Devi Narayana Superspeciality Hospital, Katra, Jammu and Kashmir, India

Correspondence Address:
Swarkar Sharma,
Mata Vaishno Devi University, Katra - 182 320, Jammu and Kashmir
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_12_19

PMID: 33533734

Gastric Carcinoma (GC) is one of the most common malignancies, which accounts for 6.8% of total cancer population worldwide. In India, the northeastern region has the highest gastric cancer incidence, and the Kashmir Valley has a very high incidence of gastric cancer as compared to other parts of Northern India. It exceeds 40% of total cancers with an incidence rate of 3–6-fold higher than other metro cities of India. Gastric cancer is a heterogeneous disease where most of the cases are sporadic, and <15% are due to obvious familial clustering. The heterogeneous nature of the disease can be associated with differences in genetic makeup of an individual. A better understanding of genetic predisposition toward GC will be helpful in promoting personalized medicine. The aim of this review is to analyze the development and progression of GC and to explore the genetic perspectives of the disease with special emphasis on Jammu and Kashmir, India.

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