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ORIGINAL ARTICLE
Year : 2022  |  Volume : 18  |  Issue : 2  |  Page : 452-460

Prognostic value of circulating tumor cells and analysis of clinicopathological factors in liver cancer


1 Department of Hepatobiliary Surgery, Shandong Cancer Hospital, Cheeloo College of Medicine, Shandong University; Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China, China, People's Republic of China
2 Department of General Surgery, The Fifth People's Hospital of Jinan, Jinan, Shandong, People's Republic of China, China, People's Republic of China
3 Hepatobiliary Surgery, Shandong Cancer Hospital, Cheeloo College of Medicine, Shandong University; Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China, China, People's Republic of China
4 Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China, China, People's Republic of China

Correspondence Address:
Sheng Li
Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250200; Shandong Cancer Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250117
People's Republic of China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.jcrt_2311_21

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Objective and Aims: The number of circulating tumor cells (CTCs) and the presence of circulating tumor microemboli (CTM) were determined in the peripheral blood of patients with liver cancer (LC). The relationship between CTCs, CTM, clinicopathologic features, and prognosis of LC was analyzed. The objective of this study was to determine the diagnostic and prognostic value of CTCs/CTM in LC. Subjects and Methods: Patients with LC were enrolled between May 2013 and August 2017, and 67 patients were included in the study. Overall survival curves were built using the Kaplan–Meier method and the log-rank test to identify risk factors. The results were analyzed using a Cox proportional hazards model and expressed as hazard ratio and 95% confidence interval (95% CI). Results: CTCs and either CTCs or CTM were detected in 27 patients (40.3%) and 29 patients (43.3%). CTM were found in four patients. One-year, 3-year, and 5-year survival rates were 42%, 20%, and 15%, respectively. Univariate Cox regression analysis showed that alpha-fetoprotein (AFP), number of CTCs, presence of CTM, and positive CTC/CTM were associated with survival time. Multivariate Cox regression analysis showed that alpha fetoprotein (AFP), number of CTCs, and presence of CTM were independent risk factors for survival in patients with LC. Conclusion: There was no significant correlation between the number of CTCs, the presence of CTM, and clinicopathologic factors. AFP, number of CTCs, and presence of CTM were independent risk factors for survival in patients with LC.


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