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REVIEW ARTICLE
Year : 2021  |  Volume : 17  |  Issue : 6  |  Page : 1307-1313

Primary gastrointestinal anaplastic large cell lymphoma: A critical reappraisal with a systematic review of the world literature


1 Deprtment of Pathology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
2 Deprtment of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
3 Deprtment of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
4 Deprtment of Medical Oncology/Hematology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

Correspondence Address:
Sonali Mohapatra
Department of Medical Oncology, All India Institute of Medical Sciences, Bhubaneswar, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_955_19

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Anaplastic large cell lymphoma (ALCL) is a distinct T-cell non-Hodgkin lymphoma involving both nodal and extra-nodal sites with a specific anaplastic lymphoma kinase 1 (ALK-1) gene rearrangement. The commonly involved extranodal sites include skin, bone, soft tissue, lungs, and liver. ALCL primarily involving gastrointestinal (GI) tract is rare. In this manuscript, we describe a case of primary esophageal ALK1 positive-ALCL (null phenotype) in a young female, who presented with fleshy mucosal lesion in the lower third of the esophagus and present a systematic review of 35 cases of GI-ALCL reported in the English literature over the past 28 years (1990–2018) with regard to the clinicopathological characteristics, therapy, and outcome.


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