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SYSTEMATIC REVIEW
Year : 2021  |  Volume : 17  |  Issue : 6  |  Page : 1297-1306

Pulmonary anaplastic large-cell lymphoma: A case-based systematic review of world literature


1 Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
2 Department of Pulmonary Medicine, Critical Care, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
3 Department of Medical Oncology/Hematology, Critical Care, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
4 Department of Biostatistics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India
5 Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar; Department of Oncopathology, Acharya Harihar Regional Cancer Institute, Cuttack, Odisha, India

Correspondence Address:
Sonali Mohapatra
Department of Medical Oncology/Hematology, All India Institute of Medical Sciences, Bhubaneswar, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_1089_19

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We describe a case of ALK1 negative (–) pulmonary anaplastic large-cell lymphoma (pALCL) in an adult female with an unfavorable outcome following combination chemotherapy and present a systematic review of 39 such sporadic cases reported over the past 28 years (1990–2018). pALCL occurred in 26 males and 13 females (median age, 43 years [5–81]) and 13/39 (33.33%) were ≤18 years. The lesions were endobronchial in 21 (53.85%) and parenchymal in 18 (46.15%) cases. Twenty-six cases were ALK1-; 13 were ALK1+ (positive); and 27/34 cases had a T cell phenotype (where tested). ALK- cases were characterized by higher age (P = 0.012) at presentation, more B symptoms (P = 0.002), and more parenchymal than endobronchial lesions (P = 0.039). The median survival (N = 29/39) was 60 months; pediatric group had a better survival than adult/elderly group (log-rank, P = 0.026). pALCL is rare and may have a distinct biological behavior.


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