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Year : 2018  |  Volume : 14  |  Issue : 1  |  Page : 119-123

Lipopolysaccharide promoted the growth rate of MG-63 cells via the extracellular regulated kinase pathway

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China

Correspondence Address:
Dr. Hao Peng
Department of Orthopedics, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan, Hubei 430060
PR China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_673_17

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Objective: The objective of this study is to investigate the effects of lipopolysaccharide (LPS) on the growth rate of MG-63 cells. Materials and Methods: MG-63 cells were exposed to various concentrations of LPS, and the growth rate was determined with the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. In addition, variations in the phosphorylation state of extracellular regulated kinase (ERK1/2), Jun N-terminal kinase, and p38 were determined by western blotting. Results: There was a correlation between the increased phosphorylation of ERK1/2 and the growth of LPS-treated MG-63 cells. The increased phosphorylation was mediated by the LPS receptor toll-like receptor-4. Conclusions: LPS promoted the growth of MG-63 cells through the ERK pathway.

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