|LETTER TO THE EDITOR
|Year : 2017 | Volume
| Issue : 2 | Page : 384-386
Adult rhabdomyosarcoma: Multimodality management and results
Abhijeet Ashok Salunke, Jaymin Shah, Nayan Gupta, Jyotindra Pandit
Department of Orthopedic Onco Surgery, Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India
|Date of Web Publication||23-Jun-2017|
Abhijeet Ashok Salunke
Department of Orthopedic Onco Surgery, Room No.13, Gujarat Cancer Research Institute, Ahmedabad
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Salunke AA, Shah J, Gupta N, Pandit J. Adult rhabdomyosarcoma: Multimodality management and results. J Can Res Ther 2017;13:384-6
We read with interest the article by Khosla et al. who have demonstrated that RMS in adults has poor prognosis as compared with childhood RMS. Adult RMS should, therefore, be treated aggressively with multidisciplinary approach comprising surgery, radiation, and chemotherapy to achieve cure and prolonged survival.
Was there any difference in survival rate in the group treated with surgery and radiotherapy and group treated with surgery, radiotherapy, and chemotherapy? According to Little et al., treatment consisted of radiation alone in 11%, radiation and surgery in 18%, radiation and chemotherapy in 34%, and all the three modalities in 37%. It would be of great interest to know what percentage of cases received multimodality treatment in the current series.
There is a high incidence of regional lymph node metastases in adult rhabdomyosarcoma ranging from 33% to 46%., Similarly, it would be of great interest to know how many cases in the current study had lymph node metastasis and what was the management.
The overall survival (OVS) and disease-free survival (DFS) are variable according to the site of tumor; so was there any difference in OVS and DFS in the current series in extremity RMS and nonextremity RMS?
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Conflicts of interest
There are no conflicts of interest.
| > References|| |
Khosla D, Sapkota S, Kapoor R, Kumar R, Sharma SC. Adult rhabdomyosarcoma: Clinical presentation, treatment, and outcome. J Cancer Res Ther 2015;11:830-4.
Little DJ, Ballo MT, Zagars GK, Pisters PW, Patel SR, El-Naggar AK, et al.
Adult rhabdomyosarcoma: Outcome following multimodality treatment. Cancer 2002;95:377-88.
Esnaola NF, Rubin BP, Baldini EH, Vasudevan N, Demetri GD, Fletcher CD, et al.
Response to chemotherapy and predictors of survival in adult rhabdomyosarcoma. Ann Surg 2001;234:215-23.