| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 12
| Issue : 5 | Page : 109-115 |
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A comparison of drug resistances of targeted drugs for advanced renal cell cancer approved by the Food and Drug Administration: A meta-analysis of randomized clinical trials
Ming Guo1, Yunsong Cao2, Jingzhe Yang3, Jingfeng Zhang2
1 Department of Hematology, 2nd Affiliated Hospital, Beijing University of Traditional Chinese Medicine, Beijing, 100078, China
2 Department of Nephrology, 2nd Affiliated Hospital, Beijing University of Traditional Chinese Medicine, Beijing, 100078, China
3 Department of Urology and Andragogy, 2nd Affiliated Hospital, Beijing University of Traditional Chinese Medicine, Beijing, 100078, China
Correspondence Address:
Jingfeng Zhang
Department of Hematology, Nephrology, 2nd Affiliated Hospital, Beijing University of Traditional Chinese Medicine, Beijing, 100078
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1482.191617
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Purpose: The purpose of this study was to conduct network meta-analysis to assess drug resistances of the Food and Drug Administration-approved drugs for advanced renal cell carcinoma.
Materials and Methods: Database searches were conducted to identify randomized controlled trials reporting results for eligible treatments. After searching for PubMed, MEDLINE, EMBASE, and ISI Web of Science, 22 studies (n = 7854 patients) were included for the comparison of drug resistance in the present meta-analysis.
Results: For overall present, the mean 6-month progression-free survival rates were 65.4%, 49.3%, 60.6%, 70.3%, 62.6%, 41.6%, 38.2%, 66.1%, 43.1%, and 17.9% for sunitinib, sorafenib, pazopanib, axitinib, bevacizumab plus interferon (IFN)-a, everolimus, temsirolimus, temsirolimus plus bevacizumab, IFN-a, and placebo, respectively. For indirect comparison, two combined therapies (bevacizumab plus IFN-a and temsirolimus plus bevacizumab) and sunitinib were of less ability of drug resistance. The risk ratio of sunitinib therapy was 3.64 (95% confidence interval [CI] [3.12, 4.25]), the risk ratio of temsirolimus plus bevacizumab therapy was 3.68 (95% CI [3.14, 4.33]), and the risk ratio of bevacizumab plus IFN-a therapy was 3.49 (95% CI [2.99, 4.06]).
Conclusions: Our results support that combination of targeted therapies might be a novel strategy against advanced renal cell carcinomas. |
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