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REVIEW ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 5  |  Page : 7-10

Roles of noncoding RNAs in metastasis of nonsmall cell lung cancer: A mini review


1 Department of Interventional Radiology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, PR China
2 Department of Oncology, Henan University School of Medicine, Kaifeng, Henan 475001, PR China

Correspondence Address:
Dr. Ruimin Sun
Department of Interventional Radiology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001
PR China
Dr. Zhijun Zhao
Department of Interventional Radiology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001
PR China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.163831

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Recent advances in genome-wide sequencing and gene expression profiling technologies has facilitated the discovery of a huge amount of long noncoding RNA (lncRNA) transcripts. In general, these lncRNAs have been reported to participate in multiple biological processes and human diseases through transcriptional, posttranscriptional and epigenetic pathway. Furthermore, emerging evidence has suggested that dysregulation of lncRNA contributes to the development and progression of human malignancies, notably lung cancer, which is one of the leading causes of cancer-related death. In this review, we will summarize the functions of lncRNAs from recent reports in human nonsmall cell lung cancer (NSCLC) research, especially in the metastasis of NSCLC, and highlight the future opportunities and challenges in diagnostics and therapy of NSCLC patients.


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