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Year : 2014  |  Volume : 10  |  Issue : 7  |  Page : 201-205

Quantitative assessment of the influence of glutathione S-transferase M1 null variant on ovarian cancer risk

1 Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2 Department of Gynecology, Tianjin Central Hospital of Gynecology Obstetrics, Nankai District, Tianjin, China
3 Department of Anorectal Surgery, Affiliated hospital to Shandong university of traditional Chinese Medicine, Jinan city, Shandong Province, 250011, China
4 Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, China

Correspondence Address:
Dr. Xipeng Zhang
Department of Colorectal Surgery, Tianjin Union Medicine Center (UMC), 190 Jieyuan Road, Hongqiao District, Tianjin 300121
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.145872

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Objective: Many studies have reported the role of glutathione S-transferase Mu 1 (GST M1) polymorphism with ovary cancer risk, but the results remained controversial. Materials and Methods: To derive a more precise estimation of the relationship, a meta-analysis was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between GSTM1 polymorphism and ovary cancer risk. A total of 11 studies including 2709 cases and 3599 controls were also involved in this meta-analysis. Results: When all the eligible studies were pooled into this meta-analysis, no significant association between ovary cancer risk and GSTM1 polymorphism was found (OR = 1.010, 95% CI = 0.911-1.121, P heterogeneity = 0.174, P = 0.848). Discussion: Our meta-analysis supports that the GSTM1 polymorphism is not contributed to the risk of ovary cancer from currently available evidence.

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