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Year : 2012  |  Volume : 8  |  Issue : 4  |  Page : 561-564

Norathyriol suppresses transformation in JB6 P+ cells by the inhibition of Akt

1 Department of Biochemistry, Guangdong Medical College, Dongguan, Guangdong, People's Republic of China, China
2 Sino-America Cancer Res Institute, Guangdong Medical College, Dongguan, Guangdong, People's Republic of China, China

Correspondence Address:
Jixia Li
Department of Biochemistry, Guangdong Medical College, Dongguan, Guangdong 523808, People's Republic of China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.106537

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Context: Chemoprevention has been acknowledged as an important and practical strategy for the management of skin cancer. Norathyriol, a naturally occurring compound present in various plants, has a potent anticancer-promoting activity. Aims: The aim was to investigate the chemopreventive activity of norathyriol on JB6 P+ cells. Materials and Methods: A soft agar assay was used to detect the effect of norathyriol on cell transformation. The activator protein-1 (AP-1) transactivation activity was examined by the luciferase assay. Results: Norathyriol inhibited epidermal growth factor (EGF)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic cell transformation in a dose-dependent manner. The activation of activator protein-1 was dose dependently suppressed by norathyriol treatment. Western blot data revealed that norathyriol attenuated the phosphorylation of Akt. Conclusions: Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation.

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