| ORIGINAL ARTICLE |
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| Year : 2012 | Volume
: 8
| Issue : 4 | Page : 549-554 |
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Cannabinoid receptor 2 is upregulated in melanoma
Zigang Zhao1, Jie Yang2, Hua Zhao1, Xiangdong Fang3, Hengjin Li1
1 Department of Dermatology, Chinese People's Liberation Army General Hospital, Beijing, China
2 Department of Dermatology, The Affiliated Hospital of North China Coal Medical College, Tangshan, China
3 Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
Correspondence Address:
Hua Zhao
Department of Dermatology, The General Hospital of the People's Liberation Army, Beijing - 100853
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1482.106534
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Aims: To investigate the expression of CB 2 in normal skin, pigmented nevus, and malignant melanoma; analyze its relation with genesis; and development of malignant melanoma.
Materials and Methods: In our study, we detected the expression of CB 2 in 20 cases of melanoma, nevus tissue, and normal skin tissues, respectively, by using immunohistochemistry, in situ hybridization, and RT-PCR. Moreover, we investigated the localization and expression of CB 2 in human melanoma cell line A375 and human immortalized keratinocyte cell line HaCaT by using immunofluorescence and western blotting.
Results: Our data revealed that CB 2 is unregulated in melanoma.
Conclusions: CB 2 plays a role in the development of melanoma. |
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