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Year : 2008  |  Volume : 4  |  Issue : 1  |  Page : 26-36

An overview on applications of optical spectroscopy in cervical cancers

1 Division of Laser Spectroscopy, Manipal Life Science Center, Manipal University, Manipal, Karnataka, India
2 Unité MéDIAN, CNRS UMR 6142, UFR Pharmacie, IFR 53, Université de Reims Champgane-Ardenne, 51 rue Cognacq - Jay, Reims Cedex, France
3 Department of Radiotherapy and Oncology, Shirdi Sai Baba Cancer Hospital, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
4 Division of Laser Spectroscopy, Manipal Life Science Center and Department of Radiotherapy and Oncology, Shirdi Sai Baba Cancer Hospital, Kasturba Medical College, Manipal University, Manipal, Karnataka, India

Correspondence Address:
Murali Krishna Chilakapati
Chilakapati Laboratory, ACTREC, TMC, Kharghar, Sector '22', Navi Mumbai - 410 208, Maharastra
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Source of Support: The data presented in the review is acquired from the project entitled "Laser spectroscopy as a predictor of tumor response to radiation therapy in cervical cancer" (2003/34/17/BRNS/1903) supported by Department of Atomic Energy; Board of Research in Nuclear Sciences, Government of India., Conflict of Interest: None

DOI: 10.4103/0973-1482.39602

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Despite advances in the treatment modalities, cervical cancers are one of the leading causes of cancer death among women. Pap smear and colposcopy are the existing screening methods and histopathology is the gold standard for diagnosis. However, these methods have been shown to be prone to reporting errors, which could be due to their subjective interpretation. Radiotherapy is the mainstay of treatment for the locally advanced stages of cervical cancers. The typical treatment regimen spans over 4 months, from the first fraction of radiation to clinical assessment of tumor response to radiotherapy. It is often noticed that due to intrinsic properties of tumors, patients with the same clinical stage and histological type respond differently to radiotherapy. Hence, there exists a need for the development of new methods for early diagnosis as well as for early prediction of tumor radioresponse. Optical spectroscopic methods have been shown to be potential alternatives for use in cancer diagnosis. In this review, we provide a brief background on the anatomy and histology of the uterine cervix and the etiology of cervical cancers; we briefly discuss the optical spectroscopic approach to cervical cancer diagnosis. A very brief discussion on radiation therapy and radiation resistance is also provided. We also share our experiences with the Raman spectroscopic methodologies in cervical cancer diagnosis as well as in the prediction of tumor radioresponse.

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