| ORIGINAL ARTICLE |
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| Year : 2007 | Volume
: 3
| Issue : 2 | Page : 81-85 |
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A prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer
KP Haresh1, PK Julka1, DN Sharma1, GK Rath1, R Prabhakar1, A Seth2
1 Department of Radiotherapy, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi - 110 029, India
2 Department of Urology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi - 110 029, India
Correspondence Address:
K P Haresh
Dept. of Radiotherapy, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi - 110 029
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1482.34684
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Aim : The aim of our study was to compare the two standard treatment approaches in muscle invasive carcinoma of urinary bladder - radical cystectomy and chemo radiation.
Materials and Methods : Transitional cell carcinoma (TCC) of bladder of stages, T2 to T4, N0/N1/N2 and MO were included in the study. Patients were allotted to two arms of the study. Arm A consisted of radical cystectomy. Adjuvant CMV chemotherapy was given for T3/T4 or Node positive disease only. Arm B received 2 cycles of neoadjuvant CMV chemo therapy followed by concurrent chemo radiation
Results : Forty-four patients were recruited into the study. Thirty patients in the surgical arm and 13 patients in the chemo radiation arm. The actuarial two-year survival rate in surgical arm is 56% while in chemo radiation arm it is 54%. There was no statistically significant difference in disease-free survival also between the two groups.
Conclusion : Chemo radiation yielded equivalent survival results with radical cystectomy. So it is worth giving preference to chemo radiation that will give a better quality of life for the patient. |
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