Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

Association of hypoxia-inducible factor-1 alpha gene polymorphism with renal cell carcinoma susceptibility


 Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, P. R, China

Correspondence Address:
Hao Huang,
Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Aim of Study: Association between hypoxia-inducible factor-1 alpha (HIF-1α) gene polymorphism and renal cell carcinoma (RCC) susceptibility is still being conflicting. This meta-analysis was performed to assess the relationship between HIF-1α C1772T (rs11549465)/G1790A (rs11549467) gene polymorphism and RCC risk. Materials and Methods: Association studies were identified from the databases of PubMed and CBM-disc (China Biological Medicine Database) as of July 1, 2015, and eligible investigations were included and synthesized using meta-analysis method. Results: Five investigations were identified, and the meta-analysis was conducted to assess the association between HIF-1α gene polymorphism and RCC risk. There was a marked association between HIF-1α C1772T TT genotype and RCC susceptibility, and the association between HIF-1α C1772T T allele/CC genotype and RCC risk was not found in overall populations (T: odds ratios [OR] =1.04, 95% confidence interval [CI]: 0.70–1.54, P = 0.84; TT: OR = 0.13, 95% CI: 1.60–2.34, P = 0.01; CC: OR = 1.18, 95% CI: 0.68–2.07, P = 0.55). Furthermore, a marked association between HIF-1α G1790A AA genotype and RCC susceptibility was found, and the association between HIF-1α G1790A A allele/GG genotype and RCC risk was not found in overall populations (A: OR = 1.53, 95% CI: 0.60–3.92, P = 0.38; AA: OR = 3.09, 95% CI: 1.38–6.92, P = 0.006; GG: OR = 0.63, 95% CI: 0.20–2.03, P = 0.44). Conclusion: HIF-1α C1772T TT genotype and HIF-1α G1790A AA genotype were associated with RCC susceptibility. However, more investigations are required to further clarify the association.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Huang L
    -  Li Mq
    -  Ou C
    -  Huang Wc
    -  Liu Jf
    -  Huang H
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed37    
    PDF Downloaded4    

Recommend this journal