Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

Association of X-ray cross-complementing group 3 Thr241Met gene polymorphism with osteosarcoma risk and its development and prognosis


1 Department of TCM Orthopedics, The First Affiliated Hospital of Xiamen University, Xiamen (Amoy) 361000, China
2 Department of TCM Orthopedics, No. 60 Center Hospital of People's Liberation Army, Dali 671000, China
3 Department of Surgery, The Affiliated Hospital of Putian University, Putian 351100, China

Correspondence Address:
Zhiyong Dong,
No. 999 Dongzhen Load, Licheng District, Putian City, Fujian Province
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Aim of Study: The relationship between X-ray cross-complementing group 3 (XRCC3) Thr241Met gene polymorphism and osteosarcoma risk and its development and prognosis is still debated. This meta-analysis was performed to assess these associations. Materials and Methods: The association studies were identified from PubMed, and eligible reports were included and calculated using meta-analysis method. Results: Interestingly, all the included studies were from Asian population. The meta-analysis indicated that XRCC3 Thr241Met gene polymorphism was associated with osteosarcoma risk (T allele: Odds ratio [OR] =1.57, 95% confidence interval [CI]: 1.25–1.98, P = 0.0001; TT genotype: OR = 2.23, 95% CI: 1.40-3.57, P = 0.0008; CC genotype: OR = 0.69, 95% CI: 0.54–0.87, P = 0.002). However, XRCC3 Thr241Met CC genotype was not associated with Enneking stage, tumor location, and tumor metastasis. Conclusion: XRCC3 Thr241Met gene polymorphism was associated with osteosarcoma risk, but XRCC3 Thr241Met CC genotype was not associated with Enneking stage, tumor location, and tumor metastasis.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Wang Y
    -  Wang G
    -  Dong Z
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed25    
    PDF Downloaded3    

Recommend this journal