Overall treatment duration with multimodality treatment approach and outcome results in oral cavity carcinoma: A study from an institute from central India
Vandana Jain1, Digpal Dharkar2, Hamsa Nandini3, Shailendra M Jain4
1 Department of Radiation Oncology, Indian Institute of Head and Neck Oncology, Indore Cancer Foundation, Indore, Madhya Pradesh, India
2 Department of Oncosurgery, Indian Institute of Head and Neck Oncology, Indore Cancer Foundation, Indore, Madhya Pradesh, India
3 Malabar Cancer Centre, Thalassery, Kerala, India
4 Department of Microbiology, Rural Medical College, Loni Bk, Maharashtra, India
Department of Radiotherapy and Oncology, Rural Medical College and Hospital, Pravara Institute of Medical Sciences DU., Loni Bk., Tal: Rahata, Ahmednagar - 413 736, Maharashtra
Source of Support: None, Conflict of Interest: None
Objective of the Study: To see the different age groups, gender, sites, disease stage, treatment outcome of various oral cavity sites carcinoma by combined modalities and the overall treatment duration.
Materials and Methods: A total of 212 oral cavity carcinoma patients (169 males and 43 females) with complete records (from September 2009 to December 2012) were analyzed for age, sex, histopathology, associated medical illnesses, various subsites with disease stage, various treatment modalities with the duration and follow-up records for disease control as well as disease failure at local, nodal, local + nodal, and distant metastasis.
Results: The most common site in oral cavity cancer was buccal mucosa 81 (38.20%). 149 (69%) patients reported were in advanced Stages III and IV of the disease. The majority of patients 149 (70.28%) were given chemotherapy + radiotherapy postoperatively (S-CRT group). The mean follow-up for all patients was 41 months (range = 21–59 months). In terms of overall disease control and metastases-free survival, the best results were (80%) for Stage I in all oral cavity sites. Irrespective of disease stage best results (59.57%) were in alveolar ridge subsite of oral cavity carcinoma.
Conclusion: Challenges are still lie ahead in treating head and neck carcinoma, as in spite of using multimodality treatment approach and biological and molecular research, the overall survival percentage has not changed much. In India as oral cavity carcinoma is in increasing trend in younger individuals massive health promotion and awareness programs targeting the risk population along with financial support for those already affected are required.