Overexpression of S100A4 protein may be associated with the development and progression of pancreatic cancer
Yong Zhou1, Zhaohua Li2, Yinlu Ding1, Jianxin Zhang3, Qifeng Yang4, Yuezhen Wu1
1 Department of General Surgery, The Second Hospital of Shandong University, Jinan 250033, China
2 Department of Medical Imaging, The Second Hospital of Shandong University, Jinan 250033, China
3 Department of Traditional Chinese Medicine, The Second Hospital of Shandong University, Jinan 250033, China
4 Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan 250012, China
Department of Breast Surgery, Qilu Hospital of Shandong University, No. 44, Culture West Road, Lixia District, Jinan 250012
Source of Support: None, Conflict of Interest: None
Aim: Accumulated evidence has suggested a relationship between S100A4 protein expression and the development and progression of pancreatic cancer (PC) while its role in diagnosis and prognosis of PC still keeps inconsistent. To obtain definitive associations between S100A4 and PC, a meta-analysis was conducted.
Materials and Methods: The PubMed and Chinese National Knowledge Infrastructure databases were electronically searched to identify studies reporting an association between S100A4 protein and PC. Statistical analyses were undergone with the utilization of STATA version 12.0 software.
Results: Nine clinical studies with a total of 545 tumor samples were included in the meta-analysis. Results revealed that increased S100A4 expression were associated with the tumor-node-metastasis stages of PC (III-IV vs. I-II: odds ratio [OR] =5.50, 95% confidence interval [95% CI] =3.13-9.67, P < 0.001). Also, compared with 1-2 histologic grade of PC samples, S100A4 protein was expressed more frequently in samples with 3-4 histologic grade (grades 1-2 vs. grades 3-4: OR = 2.57, 95% CI = 1.05-6.24, P = 0.038).
Conclusion: This meta-analysis showed that overexpression of S100A4 seems to be associated with tumor progression and poor prognosis of PC patients.