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Relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and prostate cancer susceptibility


1 Department of Urology Surgery , Sun Yat-sen University, Guangzhou 510655, China
2 Department of Nephrology, Huadu District People' Hospital, Southern Medical University, Guangzhou, China
3 Department Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou ,510655,China

Correspondence Address:
Tian-Biao Zhou,
Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655

Zong-Pei Jiang,
Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat.sen University, Guangzhou 510655

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Source of Support: None, Conflict of Interest: None

Background and Objective: Investigations on the relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and prostate cancer risk are conflicting. This meta-analysis was conducted to assess the relationship between ACE I/D gene polymorphism and prostate cancer risk. Materials and Methods: Reports were identified from PubMed, Cochrane Library, and China Biological Medicine (CBM)-disc (CBM database) on December 30, 2014, and eligible studies were recruited. Results: ACE I/D gene polymorphism was not associated with prostate cancer risk for overall populations in this meta-analysis (D allele: Odds ratio [OR] =1.56, 95% confidence interval [95% CI]: 1.00–2.46, P = 0.05; DD genotype: OR = 1.74, 95% CI: 0.95–3.20, P = 0.07; II genotype: OR = 0.67, 95% CI: 0.39–1.15, P = 0.15). Furthermore, the association of ACE I/D gene polymorphism with colorectal cancer risk was not found for the Caucasians. Interestingly, ACE I/D gene polymorphism was associated with prostate cancer risk for the Asian population and Latino population. Conclusions: There was an association between ACE I/D gene polymorphism and prostate cancer risk for the Asians and Latino population in this meta-analysis. However, more investigations should be performed to confirm this relationship.


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    -  Wang ZY
    -  Li HY
    -  Jiang ZP
    -  Zhou TB
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