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Tooth agenesis: A susceptible indicator for colorectal cancer?


 Department of Oral and Maxillofacial Pathology, Farooqia Dental College and Hospital, Mysore, Karnataka, India

Correspondence Address:
Lubna Firdose Begum,
Top Floor, No. 08, II Stage, Christian Colony, Rajiv Nagar, Mysore 570 019, Karnataka
India
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Source of Support: None, Conflict of Interest: None

Context/Background: Tooth agenesis (excluding third molars) is a common congenital disorder that affects 2.2-10% of the general  population. A number of different genes have been shown to be associated with cases of tooth agenesis including AXIN2, IRF6, FGFR1, MSX1, PAX9, and TGFA. Wingless/integration signaling gene, AXIN2, is linked to tooth agenesis and also to colorectal cancer (CRC). Aims: To analyze the correlation between tooth agenesis and CRC. Materials and Methods: The study included 50 individuals, who were divided into two groups. Group A: 25 individuals diagnosed with CRC and Group B: 25 individuals as a control group. The clinical details were recorded using preformed questionnaire, approved by ethical committee. Orthopantomogram was obtained for all the cases and controls. Results: We observed that 16% of cases and 8% of controls reported having tooth agenesis and there was no statistical significance of difference between them (P = 0.384). Among the study group, 4% reported oligodontia and 12% cases reported hypodontia. In the control group 8% reported hypodontia, there was no incidence of oligodontia. Additional finding in the study group was that 24% cases had fissured tongue which was not seen in the control group. Conclusion: Individuals with tooth agenesis might have an increased risk for CRC. A larger epidemiological study along with genetic mapping and gene sequencing is necessary to rule out the risk and relationship between tooth agenesis and CRC.


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    -  Paranjyothi M V
    -  Kumaraswamy K L
    -  Begum LF
    -  Manjunath K
    -  Litha
    -  Basheer S
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