Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

Immunohistochemical evaluation of prime molecules in cervical lesions towards assessment of malignant potentiality


1 Department of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal; Department of Materials Engineering, Indian Institute of Science, Bangalore, Karnataka, India
2 Department of Pathology, Calcutta National Medical College, Kolkata, West Bengal, India
3 Department of Radiology, Apollo Gleanengles Hospital, Kolkata, West Bengal, India
4 Department of Pathology, Midnapore Medical College and Hospital, Midnapore, West Bengal, India
5 Department of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India

Correspondence Address:
Lopamudra Das,
Department of Materials Engineering, Biomaterials and Tissue Engineering Lab, Indian Institute of Science, Bangalore - 560 012, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Objective: A comparative immunohistochemical evaluation of p63, CD105, and E-cadherin expression pattern in histopathologically confirmed normal cervical epithelium (NCM), dysplastic cervical epithelium (DYS) and squamous cell carcinoma (SCC) of uterine cervix towards assessing malignant potentiality of the precancerous condition. Materials and Methods: The biopsies from cervical mucosa (normal, dysplasia, and cancer) were studied by routine hematoxylin and eosin (H and E) and by immunohistochemistry for p63, E-cadherin, and CD105 expression. The expressions of these molecules were assessed in a semiquantitative way by (i) counting p63 cell population and distribution, (ii) intensity scoring of E-cadherin along the expression path, and (iii) measuring CD105 expression density. Result: p63 + cells were highest in carcinomas followed by dysplasia and normal. An abrupt increase in CD105 expression was observed through change of normal to dysplasia and cancer. A decrease in membranous E-cadherin expression was noticed in the transformation from normal to precancer and cancers. Conclusion: The malignant potential of the dysplastic conditions is likely to be correlated with upregulation in p63 and CD105 expression and a simultaneous downregulation of membranous E-cadherin.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Das L
    -  Naskar S
    -  Sarkar T
    -  Maiti AK
    -  Das S
    -  Chatterjee J
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed672    
    PDF Downloaded17    

Recommend this journal