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21 cases reports on haemangioma of spleen

1 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
2 Biomedical Engineering Center, Beijing University of Technology, Beijing, China

Correspondence Address:
Yuan Huang,
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021
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Source of Support: None, Conflict of Interest: None

 > Abstract 

The growing activity of hemangioma of spleen keeps unknown. To search theoretical basis for whether to take the operation, this study analyzed clinical data of 21 hemangioma patients, and 16 surgical specimens were analyzed immunohistochemistry of Ki-67, Bcl-2 and vascular endothelial growth factor (VEGF). Both 14 cases of cavernous hemangioma were positive for VEGF, and negative in capillary hemangioma, there was statistical significant difference between two types of hemangioma (P < 0.05). The most tumors had a low expression of Ki-67 with a mean ± standard deviation (SD) of 6.62 ± 6.24%, whereas the mean ± SD of Bcl-2 labeling index was 36.06 ± 19.05%. According to the statistical results, the expression of Ki-67 and Bcl-2 did not correlate with age, gender, tumor size, amount of tumor and angiomatous types. Hemangioma of spleen was one benign tumor with a tendency of slow growth. Therefore, operation should be strictly selected, we recommend observation of patients with small, asymptomatic splenic lesions, which meet the radiologic criteria for hemangiomas.

Keywords: Bcl-2, hemangioma of spleen, immunohistochemistry, Ki-67

How to cite this URL:
Huang Y, Mu G, Qin X, Lin J, Li S, Zeng Y. 21 cases reports on haemangioma of spleen. J Can Res Ther [Epub ahead of print] [cited 2017 Jan 16]. Available from: http://www.cancerjournal.net/preprintarticle.asp?id=146097



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