Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
   Table of Contents - Current issue
Coverpage
December 2016
Volume 12 | Issue 8 (Supplement)
Page Nos. 229-316

Online since Wednesday, February 22, 2017

Accessed 527 times.

PDF access policy
Full text access is free in HTML pages; however the journal allows PDF accesss only to users from developing countries and paid subscribers.

EPub access policy
Full text in EPub is free except for the current issue. Access to the latest issue is reserved only for the paid subscribers.
View as eBookView issue as eBook
Author Institution MappingAuthor Institution Mapping
Access StatisticsIssue statistics
RSS FeedRSS
Hide all abstracts  Show selected abstracts  Export selected to  Add to my list
ORIGINAL ARTICLES  

Helicobacter pylori infection and pancreatic cancer risk: A meta-analysis Highly accessed article p. 229
Yu Guo, Wei Liu, Jun Wu
DOI:10.4103/0973-1482.200744  
Objective: To assess whether the Helicobacter pylori (HP) infection can increase the risk of developing pancreatic cancer or not by meta-analysis. Methods: Published studies about HP infection and pancreatic cancer risk were electronic searched in the databases of MEDLINE, PubMed, Web of Science, and CNKI. The correlation between HP infection and pancreatic cancer was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (CI). The publication bias was assessed by Begg's funnel plot and Egger's linear regression test. Results: We finally included eight case–control studies for this present meta-analysis with 1003 pancreatic cancer patients and 1754 healthy controls. One study performed in Austria, 3 from China, and 4 from the United States. For obvious statistical heterogeneity, the data were pooled by random effects model. The pooled data indicated that significant correlation between HP infection and pancreatic cancer was found with OR = 1.45 (95% CI = 1.09–1.92) under the random effects model. The results indicated that the HP infection can significantly increase the risk of developing pancreatic cancer. The publication bias was evaluated by Begg's funnel plot and Egger's linear regression test. The Begg's funnel plot was significant asymmetric at the bottom which indicated potential publication bias. The Egger's linear regression test also indicated significant publication bias (t = 3.21, P < 0.05). Conclusion: Based on present open published data, HP infection can significantly increase the risk of developing pancreatic cancer. However, for small number of studies included in this meta-analysis and publication bias, more case–control or cohort studies are needed to further confirm this conclusion.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

O-6-methylguanine-DNA methyltransferase gene promoter methylation and lung cancer risk: A meta-analysis p. 233
Zhijia Yang, Fangjun Li
DOI:10.4103/0973-1482.200745  
Objective: To evaluate O-6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation pattern in tumor tissue and autologous controls (plasma, normal lung tissue, and bronchial lavage fluid [BLF]) in patients with nonsmall cell lung cancer (NSCLC). Materials and Methods: We electronic searched the MEDLINE and CNKI databases to find the open published studies related to MGMT gene promoter hypermethylation in NSCLC patients. The odds ratio (OR) for hypermethylation in plasma, BLF, and tissue was pooled by fixed or random effect model according to the statistical heterogeneity across the included studies. Results: After searching the related databases, we finally included 13 studies in this meta-analysis. The hypermethylation rate of tumor tissue, plasma, BLF, and control tissue of MGMT gene in NSCLC patients were 0.34 ± 0.20, 0.18 ± 0.14, and 0.39 ± 0.23; the statistical heterogeneity across the studies was evaluated by Chi-square and I2-test. Moreover, no statistical heterogeneity was existed in the aspects of hypermethylation for plasma, BLF, and tissue (P < 0.05). Meta-analysis showed the hypermethylation rate in tumor tissue was significantly higher than normal lung tissue (OR = 4.18, 95% CI: 2.76–6.32) and plasma (OR = 2.37, 95% CI: 1.49–3.75) in NSCLC patients. However, for BLF (OR = 2.05, 95% CI: 0.88–4.78), the hypermethylation rate was not statistical different (P > 0.05). Conclusion: Hypermethylation rate in MGMT gene promoter of cancer tissue was statistical higher than autologous controls which indicated that MGMT may play an important in the cancer development.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Correlation between periodontal disease and oral cancer risk: A meta-analysis p. 237
Lili Ye, Yinhua Jiang, Weidong Liu, HaiBiao Tao
DOI:10.4103/0973-1482.200746  
Objective: The purpose of this study is to investigate the correlation between periodontal disease and oral cancer risk by meta-analysis. Methods: We searched the electronic databases of PubMed and Wanfang to include the articles related to periodontal disease and oral cancer risk. The association between periodontal disease and oral cancer risk was assessed by odds ratio (OR) and its corresponding 95% confidence interval (95% CI). The publication bias was evaluated by Begg's funnel plot and Egger's line regression test. All the data analysis was done by STATA12.0 software (Stata Corporation, College Station, TX, USA). Results: Eleven case–control studies were included in our present meta-analysis. We found significant statistical heterogeneity was existed in our present meta-analysis (I2 = 99.8%, P < 0.05). Hence, the data were pooled by random effect model. The pooled results indicated a significant correlation between periodontal disease and oral cancer risk was found with OR = 3.21 and the 95% CI = 2.25–4.16 (P < 0.05). The Begg's funnel plot was obvious asymmetric indicating significant publication bias. Moreover, further Egger's line regression test also indicated significant publications (t = 3.35, P < 0.05). Conclusion: Our present meta-analysis indicated that periodontal disease can increase the oral cancer risk by nearly 2-fold.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

The diagnostic value of contrast-enhanced computed tomography imaging for detection of colorectal tumors: A meta-analysis Highly accessed article p. 241
Qing Yu, Jie Liu
DOI:10.4103/0973-1482.200747  
Objective: To evaluate the application usage of contrast-enhanced computer tomography imaging for colorectal tumors diagnosis. Methods: By searching the Medline and CNKI databases, we collected all diagnostic tests about contrast-enhanced CT imaging for colorectal tumors. Sensitivity and specificity were calculated to evaluate the usage of individual diagnostic tests. The data were analyzed using statistic software Meta-DiSc 1.4. Results: Nine trials that included a total of 4797 patients were analyzed in this study. The summary diagnosis sensitivity and specificity of contrast-enhanced CT were 0.74 (95% confidence interval [CI]: 0.71–0.77) and 0.86 (0.85–0.87), respectively. The pooled area under the receiver operating characteristic curve was 0.90. Subgroup analysis: for intravenous contrast enhancement technology, the pooled diagnosis sensitivity and specificity were 0.63 (95% CI: 0.56–0.69) and 0.89 (95% CI: 0.86–0.92); for oral contrast enhancement technology, the pooled diagnosis sensitivity and specificity were 0.78 (95% CI: 0.74–0.81) and 0.86 (95% CI: 0.84–0.87). Conclusion: Contrast-enhanced CT imaging can be regarded as an effective and feasible method for detection of the colorectal tumors.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

A meta-analysis of elemene versus DDP intrapleural injection in the treatment of malignant pleural effusion caused by lung cancer p. 244
Xiaolong Wang, Haojie Wang, Li Li
DOI:10.4103/0973-1482.200748  
Objective: The objective of this study was to evaluate the clinical efficacy of elemene versus DDP intrapleural injection in the treatment of malignant pleural effusion caused by lung cancer by meta-analysis. Materials and Methods: PubMed (1960 ~ 2016.4), EMBASE (1980 ~ 2016.4), and CNKI (1979 ~ 2016.4) databases were searched to identify the clinical studies of elemene intrapleural injection in the treatment of lung cancer malignant pleural effusion. The odds ratio (OR) was used to evaluate the clinical efficacy of elemene in the treatment of pleural effusion compared to cisplatin (DDP). Results: Seven hundred and Thirty-two subjects with 14 studies were finally included in this meta-analysis. Meta-analysis demonstrated that the objective response rate in elemene group was much higher than that in DDP group (OR = 1.34, 95% confidence interval: 1.07 ~ 1.69, P < 0.05). The Begg's funnel plot and Egger's line regression test showed no statistical publication bias. Conclusion: High clinical efficacy of elemene in the treatment of lung cancer malignant pleural effusion was found compared to DDP.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Leucine-rich repeats and immunoglobulin-like domains protein 1 and fascin actin-bundling protein 1 expression in nonsmall cell lung cancer p. 248
Juanjuan Zhang, Xiaoyan Wang, Yijie Zhang, Jingcan Wu, Nannan Zhou
DOI:10.4103/0973-1482.200749  
Objective: To assess the clinical significance of leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) and fascin actin-bundling protein 1 (Fascin-1) expression in nonsmall cell lung cancer (NSCLC). Materials and Methods: Six-one NSCLC patients were included in this study. The expression of LRIG1 and Fascin-1 was assayed in the tumor tissue and relative normal lung tissue of the 61 NSCLC patients by immunohistochemistry. The relationship between LRIG1, Fascin-1 expression pattern and lung cancer patients' clinical pathology characteristics was evaluated. Results: The positive expression rate of Fascin-1 in cancer tissue and normal tissue was 70.5% (43/61) and 13.1% (8/61), respectively, which indicated cancer tissue much higher than normal tissue (P < 0.05); for LRIG1, the positive expression rate was 54.1% (33/61) and 82.0% (50/61) for tumor tissue and normal tissue with statistical difference (P < 0.05); Fascin-1-positive expression was associated with tumor diameter (P < 0.05) and mediastinal lymph node metastasis (P < 0.05). Moreover, LRIG1-positive expression was correlated with pathology type (P < 0.05), clinical stage (P < 0.05), and mediastinal lymph node metastasis (P < 0.05). Conclusion: LRIG1 and Fascin-1 were differently expressed in cancer and normal lung tissue in patients with NSCLC, which could be a biomarker for mediastinal lymph node metastasis in NSCLC patients.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Clinical efficacy and safety of gemcitabine plus nedaplatin in the treatment of advanced nasopharyngeal carcinoma p. 252
Yan Hu, Jiang Tao Fu, Dongmei Shi, Biao Feng, Zhichao Shi
DOI:10.4103/0973-1482.200750  
Objective: The purpose was to explore the clinical effects and safety of gemcitabine plus nedaplatin in the treatment of advanced nasopharyngeal carcinoma. Materials and Methods: From March 2014 to August 2015, we recruited 63 advanced nasopharyngeal carcinoma patients in our hospital. Moreover, the 62 cases were randomly divided into control group (n = 31) and treatment group (n = 32). Patients in the control groups were treated with 5-fluorouracil 500 mg/m 2 + 500 ml 0.9% sodium chloride injection intervenous drop infusion in day 1–5 plus cisplatin 20 mg/m 2 + 500 ml 0.9% sodium chloride injection intervenous drop infusion in day 1–5 with 21 days per cycle for 3 cycles; Moreover, patients in the treatment group were given gemcitabine 1000 mg/m 2 + 500 ml 0.9% sodium chloride injection intervenous drop infusion in day 1 and 8 plus nedaplatin 20 mg/m 2 + 500 ml 0.9% sodium chloride injection intervenous drop infusion in day 1 with 21 days per cycle for 3 cycles. The objective response rate (ORR) and chemotherapy-associated toxicities were compared between the two groups. Results: After 3 cycle chemotherapy, the ORR was 41.9% and 78.1% in the control and treatment group, respectively, with statistical difference (P < 0.05); The main chemotherapy-related toxicity were hematological toxicity and gastrointestinal reaction with no statistical difference between the two groups (P > 0.05). Conclusion: The ORR was relative high for gemcitabine plus nedaplatin in the treatment of advanced nasopharyngeal carcinoma with main toxicity of hematological toxicity and gastrointestinal reaction.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

The predictive value of cervical lymph node metastasis through sentinel lymph node biopsy in patients with oral cancer: A meta-analysis p. 256
Ren Lin, Junjie Yan, Weidong Liu, Tonghai Fan, Liujun Tang
DOI:10.4103/0973-1482.200751  
Objective: The purpose of this meta-analysis was to evaluate the predictive value of cervical lymph node metastasis through sentinel lymph node biopsy (SLNB) in patients with oral cancer. Materials and Methods: Two authors independently searched the databases of PubMed, Cochrane central register of controlled trials, EMBASE, and CNKI to find the potential suitable diagnostic study related to SLNB. The diagnostic sensitivity, specificity, positive likely hood ratio (+LR), negative likely hood ratio (–LR), diagnostic odds ratio (DOR) were pooled by Meta-DiSc1.4 software. The publication bias was assessed by funnel plot and line regression test. Results: After electronic searching the related databases, we finally included twenty diagnostic studies. The pooled sensitivity, specificity, +LR, and DOR were 0.91 (95% confidence interval [CI]: 0.88–0.94), 1.00 (95% CI: 0.99–1.00), 35.52 (95% CI: 19.19–65.75), and 323.50 (95% CI: 148.27–705.83), respectively, with fixed-effect model. Moreover, the pooled –LR was 0.13 (95% CI: 0.07–0.23) by random-effect model. The area under the summary receiver operating characteristic curve of SLNB for cervical lymph node metastasis was 0.99. Conclusion: SLNB had very high sensitivity and specificity for productizing cervical lymph node metastasis in oral cancer patients.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Serum pro-gastrin-releasing peptide in diagnosis of small cell lung cancer: A meta-analysis p. 260
Hongyuan Wang, Junfeng Qian
DOI:10.4103/jcrt.JCRT_1118_16  
Objective: The purpose of this study was to assess the diagnostic sensitivity and specificity for serum pro-gastrin-releasing peptide (Pro-GRP) in diagnosis of small cell lung cancer (SCLC) through pooling all the open published data. Materials and Methods: Databases of PubMed, Cochrane, ISI Web of Knowledge, and CNKI were electronic, searched by two reviewers to find the diagnostic study serum Pro-GRP in diagnosis of SCLC. The diagnostic sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic (ROC) were calculated by Med DiSc1.4 software. Results: Finally, 21 studies were included in this meta-analysis. Because of statistical heterogeneity, the specificity, specificity, positive/negative likelihood ratio, and DOR were pooled by random effect model. The pooled sensitivity, specificity, PLR, NLR, DOR, and area under the ROC were 64% (95% confidence interval [CI]: 62%–66%), 94% (95% CI: 94%–95%), 11.87% (95% CI: 8.62–11.35), 0.32% (95% CI: 0.26%–0.39%), 40.98% (95% CI: 27.77%–60.64%), and 0.94 (95% CI: 0.91%–0.96%). Conclusion: Serum Pro-GRP was promising biomarker for SCLC diagnosis.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

X-ray cross-complementing groups 1 rs1799782 C>T polymorphisms and colorectal cancer susceptibility: A meta-analysis based on Chinese Han population p. 264
Liming Wang, Junfeng Qian, Chunxiao Ying, Yongwei Zhuang, Xingjie Shang, Fang Xu
DOI:10.4103/0973-1482.200753  
Objective: X-ray cross-complementing groups 1 (XRCC1) rs1799782 C>T polymorphisms and colorectal cancer susceptibility were not clear. The purpose of this study was to evaluate the association between XRCC1 rs1799782 C>T polymorphisms and colorectal cancer susceptibility by meta-analysis. Materials and Methods: Related databases of Medline, CNKI, and Wanfang were systematic searched for the studies related to XRCC1 rs1799782 C>T polymorphisms and colorectal cancer risk in Chinese Han population. The genotype distribution of CC, CT and TT were extracted from each included studies in the colorectal cancer patients and healthy control subjects. The odds ratio (OR) and its 95% confidence interval (95% CI) was used to assess the correlation between genetype and colorectal cancer risk. The publications for this study was evaluated by Begg's funnel plot and Egger's line regression test. Results: The median frequency of CC, CT, and TT genotype in cancer group were 48%, 41% and 11%; For control group, they were 51%, 40% and 8%; the pooled results showed that OR = 1.32 (95% CI: 1.041–1.67, P < 0.05). The pooled results indicated that XRCC1 rs1799782 C>T polymorphisms was associated with colorectal cancer susceptibility in recessive genetic model OR = 1.32 (95% CI: 1.041–1.67, P < 0.05), dominant genetic model OR = 1.21 (95% CI: 1.00–1.46, P < 0.05) and homozygous genetic model OR = 1.43 (95% CI: 1.07–1.91, P < 0.05). The funnel plot was significant asymmetric at the bottom and the Egger's test also indicated significant publication bias (t = 2.43, P = 0.04) for recessive genetic model. But, no publication bias was found in dominant and homozygous model (P > 0.05). Conclusion: Chinese Han people with rs1799782 TT/CT genotype of XRCC1 gene may have increased risk of developing colorectal.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Postoperative infectious complications after liver resection for hepatocellular carcinoma p. 268
Yuan Zhao, Yi Jin, Yueming Wu
DOI:10.4103/0973-1482.200754  
Objective: The purpose of this study was to evaluate the postoperative infectious complications after liver resection for hepatocellular carcinoma by logistic regression analysis. Materials and Methods: One hundred and sixty-six hepatocellular carcinoma patients who received surgery were retrospectively reviewed and included in this study. Of the included 166 patients, 42 patients had the postoperative infectious complications (case group) and other 124 patients did not develop postoperative infection (control group). The clinical characteristics (gender, chronic disease history) and operation-related factors were compared between the two groups. Moreover, independent risk factors for postoperative infectious complications were assessed by logistic regression analysis. Results: Statistical difference was found in the aspects of diabetes (P < 0.05), plasma albumin (P < 0.05), operation time (P < 0.05), blood loss (P < 0.05), biliary fistula (P < 0.05), and drainage time (P < 0.05). Logistic regression analysis indicated that plasma albumin <35 g/L (odds ratio [OR] =2.21, P < 0.05), blood loss >500 ml (OR = 2.65, P < 0.05), and biliary fistula (OR = 2.77, P < 0.05) were the independent risk factors for postoperative infectious complications. Conclusion: Patients with plasma albumin <35 g/L, intraoperative blood loss > 500 ml, and postoperative drainage time >72 h are more likely to develop positive infectious complications.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Effect of dezocine combined with propofol on painless gastroscopy in patients with suspect gastric carcinoma p. 271
Ji Ma, Peng Zhang, Yixuan Zhang, Zong Chen, Wenqi Xin, Donghang Zhang, Chuangeng Ma
DOI:10.4103/0973-1482.200755  
Objective: To evaluate the effect of dezocine combined with propofol on painless gastroscopy in patients with suspect gastric carcinoma. Methods: Forty-three patients with gastric carcinoma who have underwent painless gastroscopy were retrospectively analyzed. For the 43 patients, 21 patients received propofol 1 mg/kg for painless gastroscopy (control group) and other 22 cases received dezocine 20 µg/kg plus propofol 1 mg/kg for painless gastroscopy (experiment group). The vital indexes (heart rate [HR], respiratory rate [RR], mean arterial pressure [MAP], and SpO2%), side effects, and recovery time were recorded at the time point T1 (before dosing), T2 (disappearance of eyelash reflex), and T3 (recovery of orientation). Results: The HR, RR, and MAP were significantly decreased in T2 compared to T1 in both experiment and control group (P < 0.05). However, the SpO2% was not changed at T1, T2, and T3 in both experiment and control groups (P > 0.05). The RR at T2 was 16.8 ± 2.1 (n/ min) and 14.2 ± 1.8 (n/min) for experiment and control groups, respectively, with statistical difference (P < 0.05). The incidence rate of respiratory depression and body movement was 0.0%, 27.3% for experiment and 23.8%, 47.6% for control group with statistical difference (P < 0.05). The recovery time was 3.6 ± 0.8 min and 1.8 ± 0.6 min for control and experiment group, respectively, which demonstrated experiment group is much shorter than that of control group with statistical difference (P < 0.05). However, nausea and vomiting rate was not statistically different between the experiment and control groups (P > 0.05). Conclusion: Dezocine combined with propofol on painless gastroscopy can reduce the respiratory depression and body movement without interference of hemodynamics.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

A meta-analysis of contrast-enhanced ultrasound for small hepatocellular carcinoma diagnosis p. 274
Huadong Deng, Hongwei Shi, Jianming Lei, Yan Hu, Gang Li, Chaojun Wang
DOI:10.4103/0973-1482.200756  
Objective: To discuss the efficacy of contrast-enhanced ultrasound (CEUS) for diagnosis of small hepatocellular carcinoma (HCC) by pooling the open published data.Methods: A comprehensive publication electronic search was performed by reviewers in the databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure. The open published studies about CEUS for small HCC diagnosis were collected. The sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (–LR), and diagnostic odds ratio (DOR) were pooled by stata 12.0 software. Results: A total of 16 studies were included in the present study. The sensitivity, specificity, +LR, and –LR were aggregated by random effects model because of significant heterogeneity (I2 >50.0%). However, DOR was pooled by fixed effects model without significant heterogeneity (I2 <50.0%). The aggregate sensitivity was 0.86 (95% confidence interval [CI]: 0.79–0.91); the aggregate specificity was 0.87 (95% CI: 0.75–0.94); the aggregate +LR and –LR were 7.06 (95% CI: 1.64–30.36) and 0.20 (95% CI: 1.64–30.36), respectively. The DOR was 33.71 (95% CI: 20.34–55.88); the area under the receiver operating characteristic was 0.93 (95% CI: 0.90–0.95). There was significant publication bias tested by funnel plot and line regression test (t = 2.29, P < 0.05). Conclusion: With the present evidence, CEUS is useful for diagnosis of small HCC with relatively high sensitivity and specificity.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Single-lumen tracheal ventilation for minimally invasive esophagectomy in patients with esophageal cancer p. 277
Yu Bai, Yi Zhou, Xi Hua Lu
DOI:10.4103/0973-1482.200757  
Objective: The aim of this study was to observe the efficacy and safety of single-lumen tracheal ventilation for esophageal cancer surgery. Methods: Thirty-eight patients with esophageal carcinoma who prepared for minimally invasive esophagectomy were included in this study. All of the included 38 patients were received single-lumen tracheal ventilation. The arterial blood gas index was monitored through the operation procedure and recorded at four-time points: before induction (T0), at the end of chest operation (T1), at the end of the abdominal operation (T2), and 30 min after extubation (T3). The heart rate (HR) and blood pressure (BP) were also monitored and recorded during the period of PetCO2 >50 mmHg. The agitation incidence rate was also recorded in awakening period. Results: All the included 38 patients were successfully completed the operation without conversing to open thoracotomy or open laparotomy. The artificial pneumothorax time, artificial pneumoperitoneum time, and operation time were 136.6 ± 26.2 min, 104.4 ± 21.3 min, and 306.7 ± 42.0 min, respectively. The patients' BP and HR was slight elevated but within the normal range (HR <100 breaths/min and BP <140/90 mmHg) when the PetCO2 >50 mmHg. Arterial blood gas results showed that PaCO2 significantly increased in time point of T1, T2, and T3 compared to T0 (P < 0.05); PaO2 significantly increased in time point of T1 and T2 compared to T0 (P < 0.05); HR significantly increased during the operation procedure of the time points T1 (P < 0.05). Of the included 38 patients, 8 were observed preoperative blood gas PaO2 <80 mmHg and the patients had decreased PaO2 in the time point T3 compared to other 30 normal preoperative PaO2 patients. Electrocardiogram monitoring showed that all patients do not appear arrhythmia and myocardial ischemia in the process of surgery. Two of 38 patients were found of mild agitated during waking period. Conclusion: Single-lumen tracheal ventilation for esophageal cancer surgery is safe and can provide acceptable anesthesia effect.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

MutL homolog 1 expression in thyroid carcinoma and its clinical significance p. 281
Yi Lu, Baocheng Jiang, Ye Yuan, Jianping Fei, Jiyuan Wang
DOI:10.4103/0973-1482.200764  
Objective: The aim of this study was to evaluate the MutL homolog 1 (MLH1) protein expression in thyroid cancer patients and its association with clinical pathological characteristics. Materials and Methods: Forty thyroid cancer tissues and 22 partial paired normal thyroid tissues from 40 thyroid cancer patients who received surgery were collected in this study. MLH1 protein expression was tested by immunohistochemical method for the 40 cancer tissues and 22 partial paired normal thyroid tissues. The positive expression rate of MLH1 was compared between cancer tissue and normal tissue. The association between clinical pathological features such as gender, age, pathology type, clinical stage, lymph node metastasis, and MLH1 protein expression was calculated. Results: MLH1 protein was mainly expressed in the nucleus with a small amount of expression in cytoplasm. The MLH1-positive expression rates in cancer and normal tissue were 47.5% and 81.8%, respectively, with statistical difference (P = 0.008); MLH1 protein positive expression was correlated with clinical stage (P = 0.04) and cancer lymph node metastasis (P = 0.03). However, its expression was not associated with gender (P = 0.63), age (P = 0.77), and pathology type (P = 0.77). Conclusion: MLH1-negative expression may play an important role in thyroid cancer tissue development and lymph node metastasis.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Association between hepatitis B virus/hepatitis C virus infection and primary hepatocellular carcinoma risk: A meta-analysis based on Chinese population p. 284
Libo Li, Xiaolin Lan
DOI:10.4103/0973-1482.200763  
Objective: To assess the relationship between hepatitis B virus (HBV), hepatitis C virus (HCV), and HBV/HCV double infection and hepatocellular carcinoma risk in Chinese population. Materials and Methods: The databases of PubMed and CNKI were electronic searched by reviewers according to the searching words of HBV, HCV, and hepatocellular carcinoma. The related case–control studies or cohort studies were included. The association between virus infection and hepatocellular carcinoma risk was demonstrated by odds ratio (OR) and 95% confidence interval (95% CI). The data were pooled by fixed or random effects model according to the statistical heterogeneity. The publication bias was assessed by Begg's funnel plot and Egger's linear regression test. Results: Finally, 13 publications were included in this meta-analysis. For significant statistical heterogeneity (I2 = 99.8%,P = 0.00), the OR was pooled by random effects model. The pooled results showed that HBV infection can significantly increase the risk of developing hepatocellular carcinoma (OR = 58.01, 95% CI: 44.27–71.75); statistical heterogeneity analysis showed that significant heterogeneity existed in evaluation of HCV infection and hepatocellular carcinoma risk across the included 13 studies I2 = 77.78%, P = 0.00). The OR was pooled by random effects model. The pooled results showed that HCV infection can significantly increase the risk of developing hepatocellular carcinoma (OR = 2.34, 95% CI: 1.20–3.47); significant heterogeneity did not exist in evaluation HBV/HCV double infection and hepatocellular carcinoma risk for the included 13 studies (I2 = 0.00%,P = 0.80). The OR was pooled by fixed effects model. The pooled results showed that HBV/HCV double infection can significantly increase the risk of developing hepatocellular carcinoma (OR = 11.39, 95% CI: 4.58–18.20). No publication bias was found in the aspects of HBV, HCV, and HBV/HCV double infection and hepatocellular carcinoma. Conclusion: For Chinese population, HBV, HCV or HBV/HCV double infection can significantly increase the risk of developing hepatocellular carcinoma.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients p. 288
Lu Shujiao, Han Lilin, Shi Yong
DOI:10.4103/0973-1482.200762  
Objective: The purpose of this meta-analysis was to evaluate the association between cyclooxygenase-2 (Cox-2) expression and skin cancer. Materials and Methods: We searched the databases of PubMed, CNKI, and WANFANG to find the case–control studies associated with Cox-2 expression and skin cancer. The association between Cox-2 expression and skin cancer was demonstrated by odds ratio (OR) and its 95% confidence interval (95% CI). The publication bias was evaluated by funnel plot and Egger's line regression test. All the statistical analyses were done by Stata10.0 software (Stata Corporation, College Station, TX, USA). Results: Ten studies were included in this meta-analysis. Without significant statistical heterogeneity, the data were pooled by fixed-effect model. Ten case–control studies were included in this meta-analysis. The combined results showed a close correlation between Cox-2 expression and skin cancer (OR = 25.00, 95% CI: 13.40–46.64, P < 0.05) with fixed-effect model. Subgroup analysis also indicated that Cox-2 expression was significantly correlated with skin cancer with the pathology type of squamous cell carcinoma (OR = 31.95, 95% CI: 15.08–67.72, P < 0.05) and basal cell carcinoma (OR = 14.69, 95% CI: 4.80–44.94, P < 0.05). Funnel plot and Egger's line regression test indicated no publication bias. Conclusion: According to the present published data, Cox-2 expression was closely correlated to skin cancer.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Ezrin expression in the primary hepatocellular carcinoma patients and associated with clinical, pathological characteristics p. 291
Debiao Pan, Shi Wang, Hailin Ye, Shengqian Xu, Guanxiong Ye
DOI:10.4103/0973-1482.200761  
Objective: The aim of this study was to assess Ezrin expression in the primary hepatic carcinoma patients and associated with clinical, pathological characteristics. Materials and Methods: Fifty-one patients with primary hepatocellular carcinoma (PHC) with completed clinical data were retrospectively analyzed in this study. The Ezrin expression in PHC and normal control liver tissue was tested by immunohistochemical assay. The Ezrin expression and relationship with clinical characteristics were evaluated. Results: The Ezrin positive rate were 66.7% and 15.7% with expression score of 3.21 ± 1.46 and 0.60 ± 1.10, respectively, in the cancer tissue and control tissue with statistical difference (P < 0.05). The Ezrin expression was associated with the metastasis status of the patients (P < 0.05) but not associated with the age (P > 0.05), gender (P > 0.05), differentiation (P > 0.05), and tumor diameter (P > 0.05). Conclusion: Ezrin protein is highly expressed in human PHC tissue which can be used for the prediction of metastasis disease.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Gefitinib single drug in treatment of advanced esophageal cancer p. 295
Yingjun Xu, Zhihui Xie, Yan Shi, Mengwei Zhang, Jia Pan, Yanming Li, Hong Lu
DOI:10.4103/0973-1482.200760  
Objective: The objective of this study is to evaluate the clinical efficacy and toxicity of gefitinib single drug in treatment of advanced esophageal cancer. Materials and Methods: Forty-one case of advanced esophageal cancer were included from February 2012 to June 2016 in the Department of Oncology, Huaihe Hospital of Henan University. All of the included 41 cases were pathology or cytology confirmed of esophageal cancer with advanced stage with previously chemotherapy regimen of cisplatin or fluorouracil. The patients received gefitinib 250 mg/day orally until disease progression or development of unbearable drug-related toxicity. The objective response rate, overall survival, disease-free survival, and drug-related toxicity were recorded. Results: All of the 41 cases had evaluable lesions with complete response rate of 0.0% (0/41), partial response rate of 4.9% (2/41), stable disease rate of 34.1% (14/41), and progression disease rate of 61.0% (25/41). The objective response rate and disease control rate were 4.9% (2/41) and 39.0% (25/41), respectively. At the follow-up, end-point of October 2016, we observed 33 death of the included 41 patients with median disease progression time of 2.2 months and median survival time of 6.1 months; most of the drug-related toxicity was Grade 1–3 nonhematological toxicity with the incidence of Grade 1–2 rash of 51.2% (21/41), Grade 3–4 rash of 17.1% (7/41), Grade 1–2 diarrhea of 26.8% (11/41), Grade 3–4 diarrhea of 7.3% (3/41), Grade 1–2 nausea and vomiting of 14.6% (6/41). Conclusion: Gefitinib can improve the survival rate and quality of life in patients with advanced stage esophageal cancer who failed for first-line chemotherapy.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Meta-analysis of association between mobile phone use and glioma risk p. 298
Yabo Wang, Xiaqing Guo
DOI:10.4103/0973-1482.200759  
Objective: The purpose of this study was to evaluate the association between mobile phone use and glioma risk through pooling the published data. Methods: By searching Medline, EMBSE, and CNKI databases, we screened the open published case–control or cohort studies about mobile phone use and glioma risk by systematic searching strategy. The pooled odds of mobile use in glioma patients versus healthy controls were calculated by meta-analysis method. The statistical analysis was done by Stata12.0 software (http://www.stata.com). Results: After searching the Medline, EMBSE, and CNKI databases, we ultimately included 11 studies range from 2001 to 2008. For ≥1 year group, the data were pooled by random effects model. The combined data showed that there was no association between mobile phone use and glioma odds ratio (OR) =1.08 (95% confidence interval [CI]: 0.91–1.25,P > 0.05). However, a significant association was found between mobile phone use more than 5 years and glioma risk OR = 1.35 (95% CI: 1.09–1.62, P < 0.05). The publication bias of this study was evaluated by funnel plot and line regression test. The funnel plot and line regression test (t = 0.25,P = 0.81) did not indicate any publication bias. Conclusion: Long-term mobile phone use may increase the risk of developing glioma according to this meta-analysis.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Does smoking increase the risk of developing glioma? A meta-analysis based on case–control studies p. 301
Xiaqing Guo, Yabo Wang
DOI:10.4103/0973-1482.200758  
Objective: The purpose of this study was to assess the relationship between smoking and glioma risk by meta-analysis. Materials and Methods: We have searched the databases of MEDLINE, EMBASE, Ovid, and CNKI to find the suitable studies related to association between smoking and glioma risk. The pooled odds ratio (OR) and 95% confidence interval (CI) of smokers in glioma patients compared to normal controls were aggregated by statistic software Stata11.0. The publication bias was evaluated by Begg's funnel plot. Results: Finally, seven case–control studies were included in this meta-analysis. The pooled results showed that smoking did not increase the risk of glioma (OR = 0.96, 95% CI = 0.86–1.07, P > 0.05). Conclusion: No close association between smoking and glioma risk was found in this meta-analysis, which indicate that smoking may not contribute to the incidence of glioma.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

A meta-analysis to evaluate the diagnostic value of dual-time-point F-fluorodeoxyglucose positron emission tomography/computed tomography for diagnosis of pulmonary nodules p. 304
Ming Zhao, Yongfu Ma, Bo Yang, Yuqi Wang
DOI:10.4103/0973-1482.200742  
Objectives: This meta-analysis aimed at evaluating the efficacy of dual-time-point (DTP) F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) in diagnosing pulmonary nodules. Methods: Using computer and manual search, the current research about the efficacy of DTP F-FDG PET/CT in diagnosing pulmonary nodules was collected. According to the evaluation criteria of Quality Assessment of Diagnostic Accuracy Studies Scale, the data from 13 studies were analyzed by Meta-DiSc software, and the sensitivity (Sen), specificity (Spe), diagnostic odds ratios (DOR), positive likelihood ratios (LR+), and negative likelihood ratios (LR) were summarized. Results: A total of 13 articles were included in this study, involving 962 patients. The meta-analysis showed that the rough Sen of DTP PET/CT was 0.80 (95% confidence interval [CI] 0.76–0.84, I2 = 83.2%), the summary Spe was 0.75 (95% CI 0.71–0.79, I2 = 89.3%), the summary LR + and LR were 2.57 (95% CI 1.54–4.29) and 0.28 (95% CI 0.16–0.5), respectively, and DOR was 10.01 (95% CI 3.83–26.18). Conclusion: DTP F-FDG PET/CT has similar Sen and Spe, with single-time-point PET/CT in diagnosing pulmonary nodules. Further high-quality research is required to explore the potential value of DTP F-FDG PET/CT.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

The single chest tube versus double chest tube application after pulmonary lobectomy: A systematic review and meta-analysis p. 309
Xuefei Zhang, Desheng Lv, Mo Li, Ge Sun, Changhong Liu
DOI:10.4103/0973-1482.200743  
Objective: Draining of the chest cavity with two chest tubes after pulmonary lobectomy is a common practice. The objective of this study was to evaluate whether using two tubes after a pulmonary lobectomy is more effective than using a single tube. Patients and Methods: We performed a meta-analysis of five randomized studies that compared the single chest tube with double chest tube application after pulmonary lobectomy. The primary end-point was amount of drainage and duration of chest tube drainage. The secondary end-points were the patient's numbers of new drain insertion after operation, hospital stay after operation, the patient's numbers of subcutaneous emphysema after operation, the patient's numbers of residual pleural air space, pain score, the number of patients who need thoracentesis, and cost. Results: Five randomized controlled trials totaling 502 patients were included. Meta-analysis results are as follows: There were statistically significant differences in amount of drainage (risk ratio [RR] = –0.15; 95% confidence interval [CI] = –3.17, –0.12, P = 0. 03), duration of chest tube drainage (RR = –0.43; 95% CI = –0.57, –0.19, P = 0.02), pain score (P < 0.05). Compared with patients receiving the double chest tube group, there were no statistically significant differences between the two groups with regard to the patient's numbers of new drain insertion after operation. Conclusion: Compared with the double chest tube, the single chest tube significantly decreases amount of drainage, duration of chest tube drainage, pain score, the number of patients who need thoracentesis, and cost. Although there is convincing evidence to confirm the results mentioned herein, they still need to be confirmed by large-sample, multicenter, randomized, controlled trials.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Subscribe this journal
Submit articles
Most popular articles
Joiu us as a reviewer
Email alerts
Recommend this journal