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ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 8  |  Page : 288-290

Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients


1 Department of Dermatology, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China
2 Department of Thyroid and Breast Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China

Correspondence Address:
Shi Yong
Department of Thyroid and Breast Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui 323000
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.200762

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Objective: The purpose of this meta-analysis was to evaluate the association between cyclooxygenase-2 (Cox-2) expression and skin cancer. Materials and Methods: We searched the databases of PubMed, CNKI, and WANFANG to find the case–control studies associated with Cox-2 expression and skin cancer. The association between Cox-2 expression and skin cancer was demonstrated by odds ratio (OR) and its 95% confidence interval (95% CI). The publication bias was evaluated by funnel plot and Egger's line regression test. All the statistical analyses were done by Stata10.0 software (Stata Corporation, College Station, TX, USA). Results: Ten studies were included in this meta-analysis. Without significant statistical heterogeneity, the data were pooled by fixed-effect model. Ten case–control studies were included in this meta-analysis. The combined results showed a close correlation between Cox-2 expression and skin cancer (OR = 25.00, 95% CI: 13.40–46.64, P < 0.05) with fixed-effect model. Subgroup analysis also indicated that Cox-2 expression was significantly correlated with skin cancer with the pathology type of squamous cell carcinoma (OR = 31.95, 95% CI: 15.08–67.72, P < 0.05) and basal cell carcinoma (OR = 14.69, 95% CI: 4.80–44.94, P < 0.05). Funnel plot and Egger's line regression test indicated no publication bias. Conclusion: According to the present published data, Cox-2 expression was closely correlated to skin cancer.


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